ncRNA name | hsa-miR-204 |
ncRNA Category | miRNA |
Disease name | retinoblastoma (RB) |
Species | Homo sapiens |
Tissues/Cell_line | RB samples, normal retina tissues; RB cell lines Y79, WERI‐RB‐1 and SO‐RB50 |
Methods | qPCR, luciferase reporter assay, MTT assay, colony formation assay, migration and invasion assay, Western blot, in vivo growth assay |
Expression pattern | down-regulated |
Functional description | miR-204 was frequently downregulated in retinoblastoma tissues and cell lines. Enforced expression of miR-204 inhibited retinoblastoma cells' proliferation and invasion. CyclinD2 and MMP-9 were identified as potential targets of miR-204. |
PubMed ID | 25647033 |
Year | 2015 |
Title | MiR-204, down-regulated in retinoblastoma, regulates proliferation and invasion of human retinoblastoma cells by targeting CyclinD2 and MMP-9. |
Drug-related ncRNA | NO |
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